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Davierwala AP, et al.  (2005) The synthetic genetic interaction spectrum of essential genes. Nat Genet 37(10):1147-52

Abstract: The nature of synthetic genetic interactions involving essential genes (those required for viability) has not been previously examined in a broad and unbiased manner. We crossed yeast strains carrying promoter-replacement alleles for more than half of all essential yeast genes to a panel of 30 different mutants with defects in diverse cellular processes. The resulting genetic network is biased toward interactions between functionally related genes, enabling identification of a previously uncharacterized essential gene (PGA1) required for specific functions of the endoplasmic reticulum. But there are also many interactions between genes with dissimilar functions, suggesting that individual essential genes are required for buffering many cellular processes. The most notable feature of the essential synthetic genetic network is that it has an interaction density five times that of nonessential synthetic genetic networks, indicating that most yeast genetic interactions involve at least one essential gene.

Status: Published Type: Journal Article PubMed ID: 16155567

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ABD1 ACT1 ALG13 ALG14 ALG7 APC11 ARL3 ARP2 ARP7 ASK1
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Topics Genes linked to topics (#11 - 20 )
AVO1 BET3 BET5 BIM1 BNI1 BRR2 BRX1 CCA1 CDC12 CDC15
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Topics Genes linked to topics (#21 - 30 )
CDC16 CDC19 CDC27 CDC37 CDC40 CDC42 CDC45 CDC5 CDC53 CDC9
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Topics Genes linked to topics (#31 - 40 )
CDS1 CEG1 CFD1 CFT2 CIA1 CIA2 CKS1 CLF1 COG2 COG4
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Topics Genes linked to topics (#41 - 50 )
COP1 CSM3 CWC22 CWC25 DBF4 DBP10 DED81 DHR2 DOP1 DPB11
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Topics Genes linked to topics (#51 - 60 )
DPM1 DPS1 DRS1 DUT1 ECM16 EFB1 ENO2 ERD2 ERG1 ERG11
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Topics Genes linked to topics (#61 - 70 )
ERG25 ERG27 ERG7 ERO1 ESS1 EXO84 FAD1 FRQ1 FRS1 GAB1
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Topics Genes linked to topics (#71 - 80 )
GAS1 GLE1 GPI1 GPI10 GPI11 GPI16 GPI2 GRC3 GUS1 GWT1
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Topics Genes linked to topics (#81 - 90 )
HRT1 HSC82 HSP60 IPI1 IST2 JIP5 KAP95 KRE1 LAS17 LCB2
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Topics Genes linked to topics (#91 - 100 )
LCP5 LOS1 LRP1 LSM4 MAK16 MAK5 MAS1 MCD4 MCM4 MEC1
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Topics Genes linked to topics (#101 - 110 )
MES1 MET30 MOB1 MOT1 MPE1 MPS1 MRC1 MRT4 MSS4 MTR3
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Topics Genes linked to topics (#111 - 120 )
MVD1 MYO1 MYO2 NAN1 NCP1 NET1 NIP7 NOC2 NOC3 NOG2
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Topics Genes linked to topics (#121 - 130 )
NOP1 NOP14 NOP15 NOP2 NOP7 NOP8 NPL4 NSE1 NUF2 NUG1
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Topics Genes linked to topics (#131 - 140 )
NUP192 NUP85 ORC3 ORC6 OST2 PAM18 PAN1 PDS5 PFY1 PGA1
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Function/Process blue ball
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Topics Genes linked to topics (#141 - 150 )
PGA3 PHO8 PHS1 PLP2 PNO1 POB3 POL1 POL12 POL30 POL5
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Protein Processing/Modification/Regulation blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#151 - 160 )
POP1 POP4 POP5 PRE5 PRO3 PRP11 PRP16 PRP24 PRP28 PRP38
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#161 - 170 )
PRP42 PRP46 PRP5 PRP9 PRT1 PSF2 PWP1 PXR1 RAD3 RAD50
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#171 - 180 )
REB1 RER2 RFA2 RFC2 RFC3 RFC5 RFT1 RIA1 RIM2 RIX1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#181 - 190 )
RIX7 RKI1 RLP7 RNA1 RNA14 RNA15 RNT1 ROT1 RPA49 RPC10
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#191 - 200 )
RPC11 RPC17 RPC31 RPC40 RPC53 RPF1 RPL17A RPL18A RPM2 RPR2
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Genetic Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#201 - 210 )
RPS17A RPS31 RPT2 RRN11 RRN3 RRP14 RRP42 RRS1 RSC9 RTS2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#211 - 220 )
SAS10 SCH9 SDA1 SEC1 SEC10 SEC11 SEC12 SEC15 SEC17 SEC18
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Topics Genes linked to topics (#221 - 230 )
SEC2 SEC3 SEC5 SEC7 SEC8 SED5 SEN34 SEN54 SET2 SIT4
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Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#231 - 240 )
SLD2 SLD5 SLT2 SLU7 SLY1 SMC6 SMD2 SMD3 SMX2 SNU56
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Topics Genes linked to topics (#241 - 250 )
SPC19 SPC34 SPC98 SPT16 SRB6 SRB7 SRP21 SRP72 SSU72 STU1
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Topics Genes linked to topics (#251 - 260 )
SUA7 SUI2 SWC4 SWP1 TAF1 TAF10 TAF13 TAF2 TAF3 TAF7
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Topics Genes linked to topics (#261 - 270 )
TAH18 TEL2 TEM1 TEN1 TFB1 TFG1 TFG2 THS1 TIM50 TOM22
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Topics Genes linked to topics (#271 - 280 )
TOR2 TRM5 TRS20 TSC11 TSR4 TUB1 UGP1 UTP15 UTP20 UTP22
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Topics Genes linked to topics (#281 - 287 )
UTP4 UTP6 UTP9 YEF3 YPP1 ZIM17 ZPR1
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