Brengues M, et al. (2005) Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodies. Science 310(5747):486-9
Abstract: Eukaryotic cells contain non-translating mRNA concentrated in P-bodies, which are sites where the mRNA can be decapped and degraded. We present evidence that mRNAs within yeast P-bodies can also return to translation. First, inhibiting delivery of new mRNAs to P-bodies leads to their disassembly independent of mRNA decay. Second, P-bodies decline in a translation initiation-dependent manner during stress recovery. Third, reporter mRNAs concentrate in P-bodies when translation initiation is blocked and resume translation and exit P-bodies when translation is restored. Fourth, stationary phase yeast have large P-bodies containing mRNAs that re-enter translation when growth resumes. The reciprocal movement of mRNAs between polysomes and P-bodies is likely to be important in the control of mRNA translation and degradation. Moreover, because P-bodies and maternal mRNA storage granules contain related proteins, it suggests this mechanism has been widely adapted for mRNA storage.
|Status: Published||Type: Journal Article||PubMed ID: 16141371|
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