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Inadome H, et al.  (2005) Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments. Mol Cell Biol 25(17):7696-710

Abstract: The Golgi apparatus consists of a set of vesicular compartments which are distinguished by their marker proteins. These compartments are physically separated in the Saccharomyces cerevisiae cell. To characterize them extensively, we immunoisolated vesicles carrying either of the SNAREs Sed5 or Tlg2, the markers of the early and late Golgi compartments, respectively, and analyzed the membrane proteins. The composition of proteins was mostly consistent with the position of each compartment in the traffic. We found six uncharacterized but evolutionarily conserved proteins and named them Svp26 (Sed5 compartment vesicle protein of 26 kDa), Tvp38, Tvp23, Tvp18, Tvp15 (Tlg2 compartment vesicle proteins of 38, 23, 18, and 15 kDa), and Gvp36 (Golgi vesicle protein of 36 kDa). The localization of Svp26 in the early Golgi compartment was confirmed by microscopic and biochemical means. Immunoprecipitation indicated that Svp26 binds to itself and a Golgi mannosyltransferase, Ktr3. In the absence of Svp26, a considerable portion of Ktr3 was mislocalized in the endoplasmic reticulum. Our data suggest that Svp26 has a novel role in retention of a subset of membrane proteins in the early Golgi compartments.

Status: Published Type: Journal Article PubMed ID: 16107716

Topics addressed in this paper

Number of different genes curated to this paper: 55

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Topics Genes linked to topics (#1 - 10 )
AKR1 ANP1 ARF1 ATG27 DPM1 EHT1 EMP24 EMP47 ERP1 ERP2
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Topics Genes linked to topics (#11 - 20 )
ERV14 ERV25 ERV41 ERV46 GCS1 GNT1 GOS1 GVP36 KRE2 KTR1
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Topics Genes linked to topics (#21 - 30 )
KTR3 KTR4 MNN10 MNN11 MNN2 MNN5 PEP1 PEP3 PMR1 PTM1
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Topics Genes linked to topics (#31 - 40 )
RER1 SAR1 SEC12 SEC17 SEC4 SED5 SNA4 SSP120 STV1 SVP26
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Topics Genes linked to topics (#41 - 50 )
TLG2 TRS31 TVP15 TVP18 TVP23 TVP38 VAN1 VMA6 YIF1 YIP3
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Topics Genes linked to topics (#51 - 55 )
YKT6 YPT1 YPT31 YPT32 YPT52
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