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Muhlrad D and Parker R  (2005) The yeast EDC1 mRNA undergoes deadenylation-independent decapping stimulated by Not2p, Not4p, and Not5p. EMBO J 24(5):1033-45

Abstract: A major mechanism of eukaryotic mRNA degradation initiates with deadenylation followed by decapping and 5' to 3' degradation. We demonstrate that the yeast EDC1 mRNA, which encodes a protein that enhances decapping, has unique properties and is both protected from deadenylation and undergoes deadenylation-independent decapping. The 3' UTR of the EDC1 mRNA is sufficient for both protection from deadenylation and deadenylation-independent decapping and an extended poly(U) tract within the 3' UTR is required. These observations highlight the diverse forms of decapping regulation and identify a feedback loop that can compensate for decreases in activity of the decapping enzyme. Surprisingly, the decapping of the EDC1 mRNA is slowed by the loss of Not2p, Not4p, and Not5p, which interact with the Ccr4p/Pop2p deadenylase complex. This indicates that the Not proteins can affect decapping, which suggests a possible link between the mRNA deadenylation and decapping machinery.

Status: Published Type: Journal Article PubMed ID: 15706350

Topics addressed in this paper

Number of different genes curated to this paper: 23

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Topics Genes linked to topics (#1 - 10 )
CCR4 CDC36 DCP1 DCP2 DHH1 EDC1 EDC2 EDC3 LSM1 MOT2
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Topics Genes linked to topics (#11 - 20 )
NAM7 NMD2 NOT3 NOT5 PAN2 PAT1 POP2 SKI2 SKI3 SKI7
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Topics Genes linked to topics (#21 - 23 )
SKI8 UPF3 XRN1
Additional Literature blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball
Regulatory Role blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball

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