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Chen XJ, et al.  (2005) Aconitase couples metabolic regulation to mitochondrial DNA maintenance. Science 307(5710):714-7

Abstract: Mitochondrial DNA (mtDNA) is essential for cells to maintain respiratory competency and is inherited as a protein-DNA complex called the nucleoid. We have identified 22 mtDNA-associated proteins in yeast, among which is mitochondrial aconitase (Aco1p). We show that this Krebs-cycle enzyme is essential for mtDNA maintenance independent of its catalytic activity. Regulation of ACO1 expression by the HAP and retrograde metabolic signaling pathways directly affects mtDNA maintenance. When constitutively expressed, Aco1p can replace the mtDNA packaging function of the high-mobility-group protein Abf2p. Thus, Aco1p may integrate metabolic signals and mtDNA maintenance.

Status: Published Type: Journal Article PubMed ID: 15692048

Topics addressed in this paper

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Topics Genes linked to topics (#1 - 10 )
ABF2 ACO1 CHA1 CIT1 CIT2 CIT3 HAP2 HAP4 IDH1 IDP1
Cellular Location blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
ILV6 KGD1 KGD2 LPD1 LSC1 MKS1 PDA1 PDB1 RPO41 RTG1
Additional Literature blue ball blue ball
Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulatory Role blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 23 )
RTG2 SLS1 SSC1
Cellular Location blue ball blue ball
Function/Process blue ball
Genetic Interactions blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball blue ball blue ball
Strains/Constructs blue ball

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