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Fadri M, et al.  (2005) The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2. Mol Biol Cell 16(4):1883-900

Abstract: Phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P(2)] is a key second messenger that regulates actin and membrane dynamics, as well as other cellular processes. Many of the effects of PtdIns(4,5)P(2) are mediated by binding to effector proteins that contain a pleckstrin homology (PH) domain. Here, we identify two novel effectors of PtdIns(4,5)P(2) in the budding yeast Saccharomyces cerevisiae: the PH domain containing protein Slm1 and its homolog Slm2. Slm1 and Slm2 serve redundant roles essential for cell growth and actin cytoskeleton polarization. Slm1 and Slm2 bind PtdIns(4,5)P(2) through their PH domains. In addition, Slm1 and Slm2 physically interact with Avo2 and Bit61, two components of the TORC2 signaling complex, which mediates Tor2 signaling to the actin cytoskeleton. Together, these interactions coordinately regulate Slm1 targeting to the plasma membrane. Our results thus identify two novel effectors of PtdIns(4,5)P(2) regulating cell growth and actin organization and suggest that Slm1 and Slm2 integrate inputs from the PtdIns(4,5)P(2) and TORC2 to modulate polarized actin assembly and growth.

Status: Published Type: Journal Article PubMed ID: 15689497

Topics addressed in this paper

Number of different genes curated to this paper: 16

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Topics Genes linked to topics (#1 - 10 )
ACT1 ASK10 AVO2 BIT2 BIT61 CDC42 INP51 MSS4 PKC1 RGC1
Additional Literature blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball
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Genetic Interactions blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 16 )
RHO1 RHO2 SLM1 SLM2 STT4 TOR2
Cellular Location blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball
Fungal Related Genes/Proteins blue ball blue ball
Genetic Interactions blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball
Protein Processing/Modification/Regulation blue ball blue ball
Protein Sequence Features blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball
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