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Bachman N, et al.  (2004) Local definition of Ty1 target preference by long terminal repeats and clustered tRNA genes. Genome Res 14(7):1232-47

Abstract: LTR-containing retrotransposons reverse transcribe their RNA genomes, and the resulting cDNAs are integrated into the genome by the element-encoded integrase protein. The yeast LTR retrotransposon Ty1 preferentially integrates into a target window upstream of tDNAs (tRNA genes) in the yeast genome. We investigated the nature of these insertions and the target window on a genomic scale by analyzing several hundred de novo insertions upstream of tDNAs in two different multicopy gene families. The pattern of insertion upstream of tDNAs was nonrandom and periodic, with peaks separated by approximately 80 bp. Insertions were not distributed equally throughout the genome, as certain tDNAs within a given family received higher frequencies of upstream Ty1 insertions than others. We showed that the presence and relative position of additional tDNAs and LTRs surrounding the target tDNA dramatically influenced the frequency of insertion events upstream of that target.CI - Copyright 2004 Cold Spring Harbor Laboratory Press ISS.

Status: Published Type: Journal Article PubMed ID: 15197163

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Number of different genes curated to this paper: 31

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
YARCTy1-1 YBLWTy1-1 YBRWTy1-2 YDRCTy1-1 YDRCTy1-2 YDRCTy1-3 YDRWTy1-4 YDRWTy1-5 YERCTy1-1 YERCTy1-2
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DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Omics yg ball
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Topics Genes linked to topics (#11 - 20 )
YGRCTy1-2 YGRCTy1-3 YGRWTy1-1 YHRCTy1-1 YJRWTy1-1 YJRWTy1-2 YLRCTy1-1 YLRWTy1-2 YLRWTy1-3 YMLWTy1-1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
YMLWTy1-2 YMRCTy1-3 YMRCTy1-4 YNLCTy1-1 YNLWTy1-2 YOLWTy1-1 YORWTy1-2 YPLWTy1-1 YPRCTy1-2 YPRCTy1-4
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Topics Genes linked to topics (#31 )
YPRWTy1-3
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