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Banerjee D, et al.  (2004) Genome-wide expression profile of steroid response in Saccharomyces cerevisiae. Biochem Biophys Res Commun 317(2):406-13

Abstract: The response of the yeast Saccharomyces cerevisiae to human steroid hormone progesterone was studied by genomic expression profiling. The transcription profile data revealed that steroid response was a global phenomenon wherein a host of genes were affected. For example, 163 genes were upregulated and 40 genes were downregulated, by at least more than twofold. The major categories of upregulated genes included protein destination (15%), metabolism (14%), transport facilitation (12%), cell growth, cell division, and DNA synthesis (8%), and transcription (7%), while metabolism (22%), transcription (11%), intracellular transport (10%), cell growth, cell division, and DNA synthesis (10%), energy (8%), cell rescue, defense, and cell death (6%), and protein synthesis (6%) encoding genes were downregulated. Notwithstanding the fact that yeast cells do not possess commonly occurring steroid response cascade similar to higher eukaryotes, our results demonstrate that a short-term exposure to progesterone results in differential regulation of predominantly stress responsive genes.

Status: Published Type: Comparative Study | Evaluation Studies | Journal Article | Research Support, Non-U.S. Gov't | Validation Studies PubMed ID: 15063773

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ADE17 APC11 ATG31 BDH2 CDC34 CSI2 CTF13 ECM19 ECM31 ECM9
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FBP1 GAL80 GLC3 HXT6 HXT7 ICT1 IFM1 MID2 MTD1 NUF2
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OYE2 PAP2 PCL6 PDR1 PDR3 PDR5 PGM2 RNH1 RPL17B RPL4B
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Topics Genes linked to topics (#31 - 39 )
RPS3 RPS4B RPS5 RPS6B SHR5 SNQ2 TDH1 UGP1 YAP1
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