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Rubin-Bejerano I, et al.  (2003) Phagocytosis by neutrophils induces an amino acid deprivation response in Saccharomyces cerevisiae and Candida albicans. Proc Natl Acad Sci U S A 100(19):11007-12

Abstract: The transcriptional profiles of yeast cells that have been phagocytosed by either human neutrophils or monocytes were compared by using whole genome arrays. After phagocytosis by neutrophils, both Saccharomyces cerevisiae and Candida albicans respond by inducing genes of the methionine and arginine pathways. Neither of these pathways is induced upon phagocytosis by monocytes. Both fungi show a similar induction of these pathways when transferred from amino acid-rich medium to amino acid-deficient medium. These data suggest that the internal phagosome of the neutrophil is an amino acid-deficient environment.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, P.H.S. PubMed ID: 12958213

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Number of different genes curated to this paper: 103

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ADE1 ADE12 ADE13 ADE16 ADE17 ADE2 ADE3 ADE4 ADE5,7 ADE6
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Genomic expression study yg ball
Omics yg ball
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Topics Genes linked to topics (#11 - 20 )
ADE8 AKR2 ALD5 ARG1 ARG3 ARG5,6 ARG7 ARG8 ATG1 BAT1
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Topics Genes linked to topics (#21 - 30 )
BNA3 CHO2 CPA2 DUR1,2 DUR3 FAS2 FDH1 FDH2 GAP1 GAT1
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Topics Genes linked to topics (#31 - 40 )
GCN4 GLT1 GPX2 IME1 INO1 LEU1 MEP2 MET1 MET10 MET13
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Fungal Related Genes/Proteins blue ball
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Topics Genes linked to topics (#41 - 50 )
MET14 MET16 MET17 MET2 MET3 MET32 MET5 MET6 MET8 MHT1
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Topics Genes linked to topics (#51 - 60 )
MMP1 MXR1 NDE2 OAC1 OPT1 OSW2 OYE3 PAU4 PAU8 PCL5
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Topics Genes linked to topics (#61 - 70 )
PDH1 PIN2 PRM5 PUG1 RTA1 SAM3 SEO1 SER3 SHC1 SIP4
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Topics Genes linked to topics (#71 - 80 )
SMP1 SNO1 SNO2 SNZ1 SPS100 SRO77 STR3 SUL1 SUL2 TBS1
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Topics Genes linked to topics (#81 - 90 )
THI4 TOS8 TSA2 URA1 URA10 URA2 URA3 URA4 URA5 URA6
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Topics Genes linked to topics (#91 - 100 )
URA7 URA8 VMR1 VPS8 YAT2 YBR284W YCT1 YER184C YGR149W YMC2
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Topics Genes linked to topics (#101 - 103 )
YNR064C YOL106W YOR302W
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