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Kaplan CD, et al.  (2003) Transcription elongation factors repress transcription initiation from cryptic sites. Science 301(5636):1096-9

Abstract: Previous studies have suggested that transcription elongation results in changes in chromatin structure. Here we present studies of Saccharomyces cerevisiae Spt6, a conserved protein implicated in both transcription elongation and chromatin structure. Our results show that, surprisingly, an spt6 mutant permits aberrant transcription initiation from within coding regions. Furthermore, transcribed chromatin in the spt6 mutant is hypersensitive to micrococcal nuclease, and this hypersensitivity is suppressed by mutational inactivation of RNA polymerase II. These results suggest that Spt6 plays a critical role in maintaining normal chromatin structure during transcription elongation, thereby repressing transcription initiation from cryptic promoters. Other elongation and chromatin factors, including Spt16 and histone H3, appear to contribute to this control.

Status: Published Type: Journal Article PubMed ID: 12934008

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Topics Topics not linked to Genes Genes linked to topics
BUR2 FLO8 HHT1 RAD18 RPO21 SGV1 SPT10 SPT16 SPT21 SPT6
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