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Peng WT, et al.  (2003) A panoramic view of yeast noncoding RNA processing. Cell 113(7):919-33

Abstract: Predictive analysis using publicly available yeast functional genomics and proteomics data suggests that many more proteins may be involved in biogenesis of ribonucleoproteins than are currently known. Using a microarray that monitors abundance and processing of noncoding RNAs, we analyzed 468 yeast strains carrying mutations in protein-coding genes, most of which have not previously been associated with RNA or RNP synthesis. Many strains mutated in uncharacterized genes displayed aberrant noncoding RNA profiles. Ten factors involved in noncoding RNA biogenesis were verified by further experimentation, including a protein required for 20S pre-rRNA processing (Tsr2p), a protein associated with the nuclear exosome (Lrp1p), and a factor required for box C/D snoRNA accumulation (Bcd1p). These data present a global view of yeast noncoding RNA processing and confirm that many currently uncharacterized yeast proteins are involved in biogenesis of noncoding RNA.

Status: Published Type: Journal Article PubMed ID: 12837249

Topics addressed in this paper

Number of different genes curated to this paper: 34

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
BCD1 EFG1 ETS1-1 ETS1-2 ETS2-1 ETS2-2 FAP7 FYV7 GLC7 GRC3
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Omics yg ball
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Topics Genes linked to topics (#11 - 20 )
ITS2-1 ITS2-2 LRP1 MDN1 MRT4 NOP19 NOP7 RDN18-1 RDN18-2 RDN25-1
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Function/Process blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
RDN25-2 RDN37-1 RDN37-2 RDN58-1 RDN58-2 RNA1 RRP17 RRP36 SAS10 SNR128
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Function/Process blue ball blue ball
Mutants/Phenotypes blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball
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Topics Genes linked to topics (#31 - 34 )
SNR38 SNR75 TSR2 UTP22
Additional Literature blue ball blue ball
Function/Process blue ball
Mutants/Phenotypes blue ball blue ball
Primary Literature blue ball blue ball
RNA Levels and Processing blue ball blue ball
Strains/Constructs blue ball blue ball
Techniques and Reagents blue ball

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