Peng WT, et al. (2003) A panoramic view of yeast noncoding RNA processing. Cell 113(7):919-33
Abstract: Predictive analysis using publicly available yeast functional genomics and proteomics data suggests that many more proteins may be involved in biogenesis of ribonucleoproteins than are currently known. Using a microarray that monitors abundance and processing of noncoding RNAs, we analyzed 468 yeast strains carrying mutations in protein-coding genes, most of which have not previously been associated with RNA or RNP synthesis. Many strains mutated in uncharacterized genes displayed aberrant noncoding RNA profiles. Ten factors involved in noncoding RNA biogenesis were verified by further experimentation, including a protein required for 20S pre-rRNA processing (Tsr2p), a protein associated with the nuclear exosome (Lrp1p), and a factor required for box C/D snoRNA accumulation (Bcd1p). These data present a global view of yeast noncoding RNA processing and confirm that many currently uncharacterized yeast proteins are involved in biogenesis of noncoding RNA.
| Status: Published | Type: Journal Article | PubMed ID: 12837249 |
Topics addressed in this paper
Number of different genes curated to this paper: 34
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| Topics | Topics not linked to Genes | Genes linked to topics (#1 - 10 ) | |||||||||
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| BCD1 | EFG1 | ETS1-1 | ETS1-2 | ETS2-1 | ETS2-2 | FAP7 | FYV7 | GLC7 | GRC3 | ||
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| RNA Levels and Processing | | | | | |||||||
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| Topics | Genes linked to topics (#11 - 20 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ITS2-1 | ITS2-2 | LRP1 | MDN1 | MRT4 | NOP19 | NOP7 | RDN18-1 | RDN18-2 | RDN25-1 | |
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| Topics | Genes linked to topics (#21 - 30 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RDN25-2 | RDN37-1 | RDN37-2 | RDN58-1 | RDN58-2 | RNA1 | RRP17 | RRP36 | SAS10 | SNR128 | |
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| RNA Levels and Processing | | | | | | | ||||
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- To find other papers on a gene and topic, click on the colored ball in the appropriate box.
- displays other papers with information about that topic for that gene.
- displays other papers in SGD that are associated with that topic.
The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
- To go to the Locus page for a gene, click on the gene name.
| Topics | Genes linked to topics (#31 - 34 ) | |||
|---|---|---|---|---|
| SNR38 | SNR75 | TSR2 | UTP22 | |
| Additional Literature | | | ||
| Function/Process | | |||
| Mutants/Phenotypes | | | ||
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| RNA Levels and Processing | | | ||
| Strains/Constructs | | | ||
| Techniques and Reagents | | |||







