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Aburatani S, et al.  (2003) Discovery of novel transcription control relationships with gene regulatory networks generated from multiple-disruption full genome expression libraries. DNA Res 10(1):1-8

Abstract: Gene regulatory networks elucidated from strategic, genome-wide experimental data can aid in the discovery of novel gene function information and expression regulation events from observation of transcriptional regulation among genes of known and unknown biological function. To create a reliable and comprehensive data set for the elucidation of transcription regulation networks, we conducted systematic genome-wide disruption expression experiments of yeast on 118 genes with known involvement in transcription regulation. We report several novel regulatory relationships between known transcription factors and other genes with previously unknown biological function discovered with this expression library. Here we report the downstream regulatory subnetworks for UME6 and MET28. The elucidated network topology among these genes demonstrates MET28's role as a nodal point between genes involved in cell division and those involved in DNA repair mechanisms.

Status: Published Type: Journal Article PubMed ID: 12693549

Topics addressed in this paper

Number of different genes curated to this paper: 33

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ACO1 ACS1 AGA1 ARG3 ARG4 CAR1 CAR2 CPA2 CRC1 DAL1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genomic expression study yg ball
Omics yg ball
Regulation of blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#11 - 20 )
DMC1 FRE1 HEM3 HOP1 HSP12 HXK1 HXT4 IME2 INO1 KAR2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
LEU1 LYS1 MET28 OLE1 OPI3 PHO3 PHO5 PYC1 SPO13 SPO16
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball
Regulation of blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulatory Role blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball
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Topics Genes linked to topics (#31 - 33 )
STE2 UME6 ZIP1
Additional Literature blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball
Function/Process blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball
Regulation of blue ball blue ball
Regulatory Role blue ball
RNA Levels and Processing blue ball blue ball
Strains/Constructs blue ball

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