Saito R, et al. (2003) Construction of reliable protein-protein interaction networks with a new interaction generality measure. Bioinformatics 19(6):756-63
Abstract: MOTIVATION: Recent screening techniques have made large amounts of protein-protein interaction data available, from which biologically important information such as the function of uncharacterized proteins, the existence of novel protein complexes, and novel signal-transduction pathways can be discovered. However, experimental data on protein interactions contain many false positives, making these discoveries difficult. Therefore computational methods of assessing the reliability of each candidate protein-protein interaction are urgently needed. RESULTS: We developed a new 'interaction generality' measure (IG2) to assess the reliability of protein-protein interactions using only the topological properties of their interaction-network structure. Using yeast protein-protein interaction data, we showed that reliable protein-protein interactions had significantly lower IG2 values than less-reliable interactions, suggesting that IG2 values can be used to evaluate and filter interaction data to enable the construction of reliable protein-protein interaction networks.
|Status: Published||Type: Comparative Study | Evaluation Studies | Journal Article | Research Support, Non-U.S. Gov't | Validation Studies||PubMed ID: 12691988|
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