Jacinto E and Hall MN (2003) Tor signalling in bugs, brain and brawn. Nat Rev Mol Cell Biol 4(2):117-26
Abstract: TOR--a highly conserved atypical protein kinase and the 'target of rapamycin', an immunosuppressant and anti-cancer drug--controls cell growth. TOR controls the growth of proliferating yeast, fly and mammalian cells in response to nutrients. Recent findings, however, indicate that TOR also controls the growth of non-proliferating cells, such as neurons and muscle cells. Furthermore, TOR, by associating with regulatory proteins and inhibiting phosphatases, controls the activity of multiphosphorylated effectors.
|Status: Published||Type: Journal Article | Review | Review, Academic||PubMed ID: 12563289|
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