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Hwang WW, et al.  (2003) A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Mol Cell 11(1):261-6

Abstract: Monoubiquitination of histone H2B is required for methylation of histone H3 on lysine 4 (K4), a modification associated with active chromatin. The identity of the cognate ubiquitin ligase is unknown. We identify Bre1 as an evolutionarily conserved RING finger protein required in vivo for both H2B ubiquitination and H3 K4 methylation. The RING domain of Bre1 is essential for both of these modifications as is Lge1 (Large 1), a protein required for cell size control that copurifies with Bre1. In cells lacking the euchromatin-associated histone variant H2A.Z, BRE1, RAD6, and LGE1 are each essential for cell viability, supporting redundant functions for H2B ubiquitination and H2A substitution in the formation of active chromatin. Notably, analysis of mutants demonstrates a function for Bre1/Lge1-dependent H2B monoubiquitination in the control of cell size.

Status: Published Type: Journal Article PubMed ID: 12535538

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Topics Genes linked to topics
BRE1 HHT1 HHT2 HTA1 HTA2 HTB1 HTB2 HTZ1 LGE1 RAD6
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