Griffioen G and Thevelein JM (2002) Molecular mechanisms controlling the localisation of protein kinase A. Curr Genet 41(4):199-207
Abstract: cAMP-dependent protein kinases (PKA) are ubiquitous signalling molecules that mediate many extracellular signals in eukaryotes from yeast to men. Directing PKA to its substrates is an important level of control to ensure specificity of cAMP-mediated signal transduction. Unlike in yeast and fungi, in mammalian cells a relatively sophisticated insight has been obtained in the controls of PKA localisation and in fact has set the stage for future research on PKA targeting in unicellular eukaryotes. In this review, we present an integrated overview on molecular mechanisms of PKA regulatory and catalytic subunit localisation in both yeast and multicellular organisms; and we focus in more detail on recent advances of PKA localisation in the unicellular eukaryote Saccharomyces cerevisiae.
|Status: Published||Type: Journal Article | Research Support, Non-U.S. Gov't | Review||PubMed ID: 12172960|
Topics addressed in this paper
Number of different genes curated to this paper: 7
- To find other papers on a gene and topic, click on the colored ball in the appropriate box.
- displays other papers with information about that topic for that gene.
- displays other papers in SGD that are associated with that topic.
The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
- To go to the Locus page for a gene, click on the gene name.