Schneider R, et al. (2002) Unsafe SETs: histone lysine methyltransferases and cancer. Trends Biochem Sci 27(8):396-402
Abstract: Enzymes that covalently modify histones control many cellular processes by affecting gene expression. A new class of these enzymes is the histone lysine methyltransferase family, whose catalytic activity lies within a conserved domain, the SET domain. This article surveys the evidence for a connection between SET-domain-containing proteins and cancer. It proposes that deregulation of SET-domain function has an important role in carcinogenesis.
|Status: Published||Type: Journal Article | Review | Review, Tutorial||PubMed ID: 12151224|
Topics addressed in this paper
Number of different genes curated to this paper: 2
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