Decatur WA and Fournier MJ (2002) rRNA modifications and ribosome function. Trends Biochem Sci 27(7):344-51
Abstract: The development of three-dimensional maps of the modified nucleotides in the ribosomes of Escherichia coli and yeast has revealed that most (approximately 95% in E. coli and 60% in yeast) occur in functionally important regions. These include the peptidyl transferase centre, the A, P and E sites of tRNA- and mRNA binding, the polypeptide exit tunnel, and sites of subunit-subunit interaction. The correlations suggest that many ribosome functions benefit from nucleotide modification.FAU - Decatur, Wayne.
|Status: Published||Type: Journal Article | Research Support, U.S. Gov't, P.H.S.||PubMed ID: 12114023|