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Kouzarides T (2002) Histone methylation in transcriptional control. Curr Opin Genet Dev 12(2):198-209
Abstract: Over the past year or so, methylation of histones has come to be recognised as a major player in the regulation of gene activity. This notion follows the discovery of lysine and arginine methyltransferases and proteins that recognise the methyl-lysine 'mark' on histones. Methylated histones have been implicated in heterochromatic repression, promoter regulation and the propagation of a repressed state via DNA methylation.
| Status: Published | Type: Journal Article | Review | Review, Tutorial | PubMed ID: 11893494 |
Topics addressed in this paper
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