Whitmarsh AJ and Davis RJ (1999) Signal transduction by MAP kinases: regulation by phosphorylation-dependent switches. Sci STKE 1999(1):PE1
Abstract: The kinases of mitogen-activated protein (MAP) kinase cascades transmit signals through sequential phosphorylation and activation of the enzymes. However, recent evidence indicates that protein-protein interactions between the kinases themselves or with substrates or other components are also a critical means of regulation. Whitmarsh and Davis summarize these findings with emphasis on new evidence from yeast that, when phosphorylated, a MAP kinase kinase actually switches from a negative regulator that binds to and inhibits its target MAP kinase to a positive regulator of that same enzyme.
|Status: Published||Type: Journal Article | Review||PubMed ID: 11865181|
Topics addressed in this paper
Number of different genes curated to this paper: 5
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