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Marc P, et al.  (2002) Genome-wide analysis of mRNAs targeted to yeast mitochondria. EMBO Rep 3(2):159-64

Abstract: It is agreed that nuclear-encoded mitochondrial proteins are post-translationally targeted to mitochondria, even if, in some cases, a co-translational phase can assist the import of precursor proteins. We used yeast DNA microarrays to analyse the mRNA populations associated with free and mitochondrion-bound polysomes. As expected, many mRNAs, known to encode mitochondrial proteins, are localized to free cytoplasmic polysomes, but many are localized to mitochondrion-bound polysomes. Furthermore, the 3'-UTR of six randomly chosen mitochondrion-bound mRNAs contains sufficient information to target, in vivo, non-translatable RNA to the vicinity of mitochondria. Interestingly, genes producing mRNAs that are targeted to mitochondria are mainly of ancient bacterial origin, whereas those producing mRNAs that are translated in the cytoplasm are mainly of eukaryotic origin. These observations, which support the recent hypotheses concerning the dual origin of the mitochondrial proteome, provide new insights into the biogenesis of mitochondria.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't PubMed ID: 11818335

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ACO1 AFG1 AHP1 ALD4 ATP1 ATP17 ATP2 ATP20 ATP3 BSC2
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CCP1 CDC9 CIT1 CIT3 COQ4 COQ5 COR1 COX12 COX13 COX9
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Topics Genes linked to topics (#21 - 30 )
CPR3 CTP1 ERV2 ETR1 FMN1 FZO1 GCV1 GCV3 IDP1 IFA38
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Topics Genes linked to topics (#31 - 40 )
ILV1 INH1 LAT1 LSC2 MCR1 MDH1 MET7 MRPL38 MRPS17 MSS116
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Topics Genes linked to topics (#41 - 50 )
MSS51 NDI1 PDA1 PDB1 POR1 PPE1 PUS5 QCR7 SDH2 STF2
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Topics Genes linked to topics (#51 - 56 )
TIM54 TOM7 TUF1 UIP3 UPS1 YJL045W
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