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Harnpicharnchai P, et al.  (2001) Composition and functional characterization of yeast 66S ribosome assembly intermediates. Mol Cell 8(3):505-15

Abstract: The pathway and complete collection of factors that orchestrate ribosome assembly are not clear. To address these problems, we affinity purified yeast preribosomal particles containing the nucleolar protein Nop7p and developed means to separate their components. Nop7p is associated primarily with 66S preribosomes containing either 27SB or 25.5S plus 7S pre-rRNAs. Copurifying proteins identified by mass spectrometry include ribosomal proteins, nonribosomal proteins previously implicated in 60S ribosome biogenesis, and proteins not known to be involved in ribosome production. Analysis of strains mutant for eight of these proteins not previously implicated in ribosome biogenesis showed that they do participate in this pathway. These results demonstrate that proteomic approaches in concert with genetic tools provide powerful means to purify and characterize ribosome assembly intermediates.

Status: Published Type: Journal Article PubMed ID: 11583614

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Topics Genes linked to topics (#1 - 10 )
BRX1 CIC1 DRS1 EBP2 ERB1 HAS1 LOC1 MAK16 MRT4 NIP7
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NOG1 NOP15 NOP16 NOP7 NSA1 NSA2 RLP24 RLP7 RPF1 RRP1
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Topics Genes linked to topics (#21 - 23 )
SPB1 TIF6 YTM1
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