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Lawler JF Jr, et al.  (2001) Frameshift signal transplantation and the unambiguous analysis of mutations in the yeast retrotransposon Ty1 Gag-Pol overlap region. J Virol 75(15):6769-75

Abstract: The yeast retrotransposon Ty1 encodes a 7-nucleotide RNA sequence that directs a programmed, +1 ribosomal frameshifting event required for Gag-Pol translation and retrotransposition. We report mutations that block frameshifting, which can be suppressed in cis by "transplanting" the frameshift signal to a position upstream of its native location. These "frameshift transplant" mutants transpose with only a modest decrease in efficiency, suggesting that the location of the frameshift signal in a functional Ty1 element may vary. The genomic architecture of Ty1 is such that Gag, Ty1 PR (PR), and the Gag-derived p4 peptide share a common sequence. The functional independence of the movement of the frameshift signal to a new location within the Ty1 element is used to unambiguously attribute the effect of mutations deleterious to transposition in this region of overlapping coding sequences to effects on the Ty1 (PR). This work defines the amino terminus of the Ty1 PR and introduces a new technique for studying viral genome organization.

Status: Published Type: Journal Article PubMed ID: 11435555

Topics addressed in this paper

Number of different genes curated to this paper: 93

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Topics Genes linked to topics (#1 - 10 )
YAR009C YAR010C YARCTy1-1 YBL005W-A YBL005W-B YBLWTy1-1 YBR012W-A YBR012W-B YBRWTy1-2 YDR098C-A
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Topics Genes linked to topics (#11 - 20 )
YDR098C-B YDR170W-A YDR210C-C YDR210C-D YDR261C-C YDR261C-D YDR316W-A YDR316W-B YDR365W-A YDR365W-B
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
YDRCTy1-1 YDRCTy1-2 YDRCTy1-3 YDRWTy1-4 YDRWTy1-5 YER137C-A YER138C YER159C-A YER160C YERCTy1-1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
YERCTy1-2 YGR027W-A YGR027W-B YGR038C-A YGR038C-B YGR161C-C YGR161C-D YGRCTy1-2 YGRCTy1-3 YGRWTy1-1
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Topics Genes linked to topics (#41 - 50 )
YHR214C-B YHR214C-C YHRCTy1-1 YJR026W YJR027W YJR028W YJR029W YJRWTy1-1 YJRWTy1-2 YLR035C-A
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Topics Genes linked to topics (#51 - 60 )
YLR157C-A YLR157C-B YLR227W-A YLR256W-A YLRCTy1-1 YLRWTy1-2 YLRWTy1-3 YML039W YML040W YML045W
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Translational Regulation blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#61 - 70 )
YML045W-A YMLWTy1-1 YMLWTy1-2 YMR045C YMR046C YMR050C YMR051C YMRCTy1-3 YMRCTy1-4 YNL054W-A
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#71 - 80 )
YNL054W-B YNL284C-A YNL284C-B YNLCTy1-1 YNLWTy1-2 YOL103W-A YOL103W-B YOLWTy1-1 YOR142W-A YOR142W-B
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#81 - 90 )
YORWTy1-2 YPL257W-A YPL257W-B YPLWTy1-1 YPR137C-A YPR137C-B YPR158C-C YPR158C-D YPR158W-A YPR158W-B
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Translational Regulation blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#91 - 93 )
YPRCTy1-2 YPRCTy1-4 YPRWTy1-3
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