Rosenberg SM (2001) Evolving responsively: adaptive mutation. Nat Rev Genet 2(7):504-15
Abstract: A basic principle of genetics is that the likelihood that a particular mutation occurs is independent of its phenotypic consequences. The concept of adaptive mutation seemed to challenge this principle with the discoveries of mutations stimulated by stress, some of which allow adaptation to the stress. The emerging mechanisms of adaptive genetic change cast evolution, development and heredity into a new perspective, indicating new models for the genetic changes that fuel these processes.
|Status: Published||Type: Journal Article | Research Support, U.S. Gov't, P.H.S. | Review||PubMed ID: 11433357|