Havas K, et al. (2000) Generation of superhelical torsion by ATP-dependent chromatin remodeling activities. Cell 103(7):1133-42
Abstract: ATP-dependent chromatin remodeling activities participate in the alteration of chromatin structure during gene regulation. All have DNA- or chromatin-stimulated ATPase activity and many can alter the structure of chromatin; however, the means by which they do this have remained unclear. Here we describe a novel activity for ATP-dependent chromatin remodeling activities, the ability to generate unconstrained negative superhelical torsion in DNA and chromatin. We find that the ability to distort DNA is shared by the yeast SWI/SNF complex, Xenopus Mi-2 complex, recombinant ISWI, and recombinant BRG1, suggesting that the generation of superhelical torsion represents a primary biomechanical activity shared by all Snf2p-related ATPase motors. The generation of superhelical torque provides a potent means by which ATP-dependent chromatin remodeling activities can manipulate chromatin structure.
|Status: Published||Type: Journal Article | Research Support, Non-U.S. Gov't||PubMed ID: 11163188|
Topics addressed in this paper
Number of different genes curated to this paper: 12
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|Topics||Genes (#1 - 10 )|
|Non-Fungal Related Genes/Proteins|
|Protein Sequence Features|