Grote E, et al. (2000) Ordering the final events in yeast exocytosis. J Cell Biol 151(2):439-52
Abstract: In yeast, assembly of exocytic soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor (SNARE) complexes between the secretory vesicle SNARE Sncp and the plasma membrane SNAREs Ssop and Sec9p occurs at a late stage of the exocytic reaction. Mutations that block either secretory vesicle delivery or tethering prevent SNARE complex assembly and the localization of Sec1p, a SNARE complex binding protein, to sites of secretion. By contrast, wild-type levels of SNARE complexes persist in the sec1-1 mutant after a secretory block is imposed, suggesting a role for Sec1p after SNARE complex assembly. In the sec18-1 mutant, cis-SNARE complexes containing surface-accessible Sncp accumulate in the plasma membrane. Thus, one function of Sec18p is to disassemble SNARE complexes on the postfusion membrane.
|Status: Published||Type: Journal Article | Research Support, U.S. Gov't, P.H.S.||PubMed ID: 11038189|
Topics addressed in this paper
Number of different genes curated to this paper: 12
- To go to the Locus page for a gene, click on the gene name.
|Topics||Genes (#1 - 10 )|
|Topics||Genes (#11 - 12 )|