---

Bannister AJ and Miska EA  (2000) Regulation of gene expression by transcription factor acetylation. Cell Mol Life Sci 57(8-9):1184-92

Abstract: In the nucleus, DNA is tightly packaged into higher-order structures, generating an environment that is highly repressive towards DNA processes such as gene transcription. Acetylation of lysine residues within proteins has recently emerged as a major mechanism used by the cell to overcome this repression. Acetylation of non-histone proteins, including transcription factors, as well as histones, appears to be involved in this process. Like phosphorylation, acetylation is a dynamic process that can regulate protein-DNA and protein-protein interactions. Moreover, a conserved domain, the bromodomain, has been implicated in the binding of acetylated peptides, suggesting a role for acetylation in intracellular signalling.

Status: Published

Type: Journal Article | Research Support, Non-U.S. Gov't | Review

PubMed ID: 11028911

---

Author Searches

To find contact information or other publications by the authors of this paper, follow these three steps:

1. (1) Choose an author,
2. (2) Choose a search parameter,
3. (3) Click to implement

Bannister AJ Miska EA Papers in SGD Colleagues in SGD PubMed Google Scholar

---