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Rout MP, et al.  (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148(4):635-51

Abstract: An understanding of how the nuclear pore complex (NPC) mediates nucleocytoplasmic exchange requires a comprehensive inventory of the molecular components of the NPC and a knowledge of how each component contributes to the overall structure of this large molecular translocation machine. Therefore, we have taken a comprehensive approach to classify all components of the yeast NPC (nucleoporins). This involved identifying all the proteins present in a highly enriched NPC fraction, determining which of these proteins were nucleoporins, and localizing each nucleoporin within the NPC. Using these data, we present a map of the molecular architecture of the yeast NPC and provide evidence for a Brownian affinity gating mechanism for nucleocytoplasmic transport.

Status: Published Type: Journal Article PubMed ID: 10684247

Topics addressed in this paper

Number of different genes curated to this paper: 66

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Topics Genes linked to topics (#1 - 10 )
AIM4 ASM4 BMS1 BUD20 CTR9 ETT1 GLE1 GLE2 HAS1 KAP120
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Topics Genes linked to topics (#11 - 20 )
KAP122 KAP123 KAP95 KRR1 MEX67 MLP1 MLP2 NDC1 NIC96 NOC2
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Topics Genes linked to topics (#21 - 30 )
NOC4 NOG1 NOG2 NOP14 NOP16 NOP53 NOP7 NSA2 NSP1 NUG1
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Topics Genes linked to topics (#31 - 40 )
NUP1 NUP100 NUP116 NUP120 NUP133 NUP145 NUP157 NUP159 NUP170 NUP188
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Topics Genes linked to topics (#41 - 50 )
NUP192 NUP2 NUP42 NUP49 NUP53 NUP57 NUP60 NUP82 NUP84 NUP85
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Topics Genes linked to topics (#51 - 60 )
OLA1 POM152 POM34 RRB1 RRP17 RSA1 RVB1 SEH1 SNU13 SRP1
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Topics Genes linked to topics (#61 - 66 )
TDA3 TMA46 TPA1 YDL121C YHR127W YRB2
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