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Arnold RJ, et al.  (1999) The action of N-terminal acetyltransferases on yeast ribosomal proteins. J Biol Chem 274(52):37035-40

Abstract: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was used to determine the state of N-terminal acetylation of 68 ribosomal proteins from a normal strain of Saccharomyces cerevisiae and from the ard1-Delta, nat3-Delta, and mak3-Delta mutants (4), each lacking a catalytic subunit of three different N-terminal acetyltransferases. A total 30 of the of 68 ribosomal proteins were N-terminal-acetylated, and 24 of these (80%) were NatA substrates, unacetylated in solely the ard1-Delta mutant and having mainly Ac-Ser- termini and a few with Ac-Ala- or Ac-Thr- termini. Only 4 (13%) were NatB substrates, unacetylated in solely the nat3-Delta mutant, and having Ac-Met-Asp- or Ac-Met-Glu- termini. No NatC substrates were uncovered, e.g. unacetylated in solely mak3-Delta mutants, consistent with finding that none of the ribosomal proteins had Ac-Met-Ile-, Ac-Met-Leu-, or Ac-Met-Phe- termini. Interestingly, two new types of the unusual NatD substrates were uncovered, having either Ac-Ser-Asp-Phe- or Ac-Ser-Asp-Ala- termini that were unacetylated in the ard1-Delta mutant, and only partially acetylated in the mak3-Delta mutant and, for one case, also only partially in the nat3-Delta mutant. We suggest that the acetylation of NatD substrates requires not only Ard1p and Nat1p, but also auxiliary factors that are acetylated by the Mak3p and Nat3p N-terminal acetyltransferases.

Status: Published Type: Journal Article PubMed ID: 10601260

Topics addressed in this paper

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Topics Genes linked to topics (#1 - 10 )
ARD1 MAK3 NAT1 NAT3 PDC1 RPL10 RPL11A RPL11B RPL14A RPL15A
Additional Literature blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball
Fungal Related Genes/Proteins blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball
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Strains/Constructs blue ball blue ball blue ball blue ball
Substrates/Ligands/Cofactors blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
RPL16A RPL16B RPL17A RPL19A RPL1A RPL1B RPL21A RPL22A RPL25 RPL26B
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball
Protein Processing/Modification/Regulation blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
RPL27A RPL28 RPL29 RPL2A RPL3 RPL30 RPL31A RPL32 RPL33A RPL36A
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball
Protein Processing/Modification/Regulation blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
RPL36B RPL38 RPL39 RPL42B RPL4A RPL6A RPL7A RPL8A RPP1A RPP2A
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Topics Genes linked to topics (#41 - 50 )
RPP2B RPS0B RPS10A RPS10B RPS11A RPS13 RPS14A RPS15 RPS16A RPS18A
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Processing/Modification/Regulation blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#51 - 60 )
RPS18B RPS19B RPS1A RPS2 RPS20 RPS21A RPS21B RPS22A RPS24A RPS27A
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Protein Processing/Modification/Regulation blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#61 - 70 )
RPS27B RPS28A RPS28B RPS29A RPS29B RPS3 RPS30A RPS30B RPS4A RPS5
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Processing/Modification/Regulation blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#71 - 73 )
RPS7A RPS7B RPS8A
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