Ontology: Molecular Function (GO:0004367)

Definition: Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+.

Synonyms: alpha-glycerol phosphate dehydrogenase (NAD) activity; alpha-glycerophosphate dehydrogenase (NAD) activity; glycerol 1-phosphate dehydrogenase activity; glycerol phosphate dehydrogenase (NAD) activity; glycerol-3-phosphate dehydrogenase (NAD) activity; glycerophosphate dehydrogenase (NAD) activity; hydroglycerophosphate dehydrogenase activity; L-alpha-glycerol phosphate dehydrogenase activity; L-alpha-glycerophosphate dehydrogenase activity; L-glycerol phosphate dehydrogenase activity; L-glycerophosphate dehydrogenase activity; NAD-alpha-glycerophosphate dehydrogenase activity; NAD-dependent glycerol phosphate dehydrogenase activity; NAD-dependent glycerol-3-phosphate dehydrogenase activity; NAD-L-glycerol-3-phosphate dehydrogenase activity; NAD-linked glycerol 3-phosphate dehydrogenase activity; NADH-dihydroxyacetone phosphate reductase activity

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term glycerol-3-phosphate dehydrogenase [NAD+] activity (2 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	glycerol-3-phosphate dehydrogenase [NAD+] activity	2
High-throughput	none	none
Computational (download data)	glycerol-3-phosphate dehydrogenase [NAD+] activity	2

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term glycerol-3-phosphate dehydrogenase [NAD+] activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

glycerol-3-phosphate dehydrogenase [NAD+] activity      2 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
GPD1/YDL022W	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Albertyn J, et al.  (1994) GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathway. Mol Cell Biol 14(6):4135-44	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR006168, EBI:IPR017751 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with IUBMB:1.1.1.8 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
GPD2/YOL059W	IMP: Inferred from Mutant Phenotype Assigned on 2002-07-23	manually curated	Ansell R, et al.  (1997) The two isoenzymes for yeast NAD+-dependent glycerol 3-phosphate dehydrogenase encoded by GPD1 and GPD2 have distinct roles in osmoadaptation and redox regulation. EMBO J 16(9):2179-87	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR017751, EBI:IPR006168 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with IUBMB:1.1.1.8 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB

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